Fred Burkle from Angel
Of all the characters created and destroyed by Joss Whedon, Fred's (Amy Acker) arc was particularly depressing. Fred spent years in the hell dimension enslaved by demons until she was rescued and regained her independence on Angel, the Buffy spin-off. Fred’s depressing past was only made harder to witness her plight. Illyria the demon not only killed Fred, but also possessed her body, destroying her soul—and a peaceful eternity—along with it.
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