Teri Hatcher and Marcia Cross
These two played seamless best friends on Desperate Housewives, but they truly hated one another in real life. Their biggest fight was actually on set during a Vanity Fair shoot. Hatcher was supposedly trying to steal the spotlight, micro-manage the photographer, and make the shoot about herself. Cross ended up blowing up and threatening to walk off set if Hatcher didn't quit it.
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