Plague of Justinian
The Plague of Justinian is one of the worst plagues in human history, but not much is known about it. After being struck by the bubonic plague, the Byzantine Empire (then led by Emporer Justinian, hence the name) began a steady decline. The plague took a while to die off, restarting again periodically for several years. Historians estimated that about 10% of the entire world population perished as a result.
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