Actors Who Never Recovered From Their Most Distressing Roles

Drew Barrymore in Scream

Drew Barrymore played an iconic role in the opening scene of Scream, but the actress was actually just as worked up behind the scenes as she was on-screen. Barrymore knew how to get her adrenaline pumping in preparation for the week-long shoot: she told Wes Craven her "secrets," which he would then relay to her in private to make her cry. Barrymore wanted to hyperventilate, and day after day, Craven managed to prod her into sobbing and shrieking and sprinting all over the set.

"It was intense," she said. "I remember driving home the night I wrapped and I was beat. I was exhausted."